MicroRNAs in Asthma and Respiratory Infections: Identifying Common Pathways

摘要: MicroRNAs (miRs) are single-stranded RNAs of 18-25 nucleotides. These molecules regulate gene expression at the post-transcriptional level; several these differentially expressed in asthma as well viral acute respiratory infections (ARIs), main triggers exacerbations. In recent years, miRs have been studied order to discover drug targets biomarkers for diagnosis, disease severity and prognosis. We describe findings on miR function their role regulation ARIs, according cell tissue specificity severity. By combining above information, we identify that may be important virus-induced This is first attempt link profiles asthmatic patients ARI-induced miRs, addressing question whether there might a specific deficit subjects make them more susceptible and/or reactive infection.