Lymph node involvement in advanced gastroesophageal junction adenocarcinoma.

摘要: Objective The prognosis of gastroesophageal junction adenocarcinoma is unquestionably related to the extent nodal involvement; nonetheless, few studies deal with pattern lymph node spread and specifically analyze prognostic value site metastasis. present study was aimed at evaluating these key aspects in advanced adenocarcinoma. Methods Of 219 patients consecutively operated on for Department General Surgery Surgical Oncology, University Siena, Surgery, Verona, 143 pT2-4 tumors not submitted prior chemoradiation were analyzed according Japanese Gastric Cancer Association pN staging system. Results majority given diagnoses metastases (77.6%). mean number ( P = .076) percentage + disease .022) progressively increased from Siewert type I III tumors. Abdominal nodes involved all but 1 disease; conversely, into chest 46.2% I, 29.5% II, 9.3% Survival analysis showed virtually no chance recovery more than 6 metastatic or located beyond first tier. Conclusions In adenocarcinoma, high frequency unfavorable long-term outcome achieved by means surgical intervention alone are indicative need aggressive multimodal treatment along improve results.