Circling behaviour following unilateral kainic acid injections into rat striatum

摘要: Abstract Unilateral injection of kainic acid (2,5–25 nmol) into rat anterior caudate-putamen induced dose-related circling behaviour. Kainic (10 consistently caused initial weak ipsiversive lasting 1 h followed by prolonged strong contraversive rotation in excess 10 h. intrastriatal administration L-glutamic acid, or monosodium L-glutamate, to normal rats, L-glutamate rats with extensive decortication, did not induce The simultaneous unilateral (1 μ mol) nmol)_did modify behaviour acid. However, decortication greatly reduced instratriatal nmol), an effect reversed the mol). 6-hydroxydopamine lesions left nigrostriatal pathway abolished and potentiated subsequent for u p 4 after nmol). Peripheral haloperidol mg/kg i.p.) also decreased rotation. Electro-coagulation ipsilateral strio-nigral produced but markedly attenuated These findings suggest that depends on intact corticostriate pathways, it cannot be reproduced modified glutamate. appears mediated via modulated dopaminergic function.