A ‘preformed chelate approach’ model for coupling amine-modified rhenium and technetium ‘3+1’ mixed ligand complexes to carboxylate residues

摘要: Abstract Selected ‘3+1’ mixed ligand oxorhenium and oxotechnetium complexes containing the SNS/S donor atom set have been modified by introduction of a bifunctional amine anchor on p -position thiophenolato monodentate ligand. A representative series several tridentate ligands was prepared both at macromolar (Re complexes) nanomolar ( 99m Tc amounts. Coupling these to activated carboxylate groups performed according ‘preformed chelate approach’ using benzoyl chloride as model molecule. yields were high millimolar metal concentration, revealed high-performance liquid chromatographic analysis Re species adopting parallel radiometric photometric detection modes. All compounds characterized classical analytical methods. In addition, structures parent ReO[CH 3 SCH 2 CH N(CH S) ][ -SC 6 H 4 NH ] daughter NHCOC 5 solved X-ray crystallography. Both adopt distorted trigonal bipyramidal geometry around rhenium, wherein oxo group sulfur atoms SNS occupy equatorial plane nitrogen monothiol are located apical positions trans each other.