Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation.
作者： Leandro Soriano-Guillén , Vicente Barrios , Ángel Campos-Barros , Jesús Argente
DOI: 10.1016/J.JPEDS.2003.10.036
关键词:
摘要: Abstract Objective To study the influence of dietary intervention on plasma ghrelin levels in obese children and adolescents with anorexia nervosa (AN). Study design Prepubertal (n = 16) 16 anorexic were studied at three different points: clinical diagnosis after a reduction or recuperation 25% 50% initial BMI SD score. Controls included 21 Tanner growth stage 1 36 5 subjects. We analyzed their correlation leptin, insulin, insulin-like factor I (IGF-I), binding protein (IGFBP-1), 2 (IGFBP-2), 3 (IGFBP-3), integrated concentration hormone (ICGH) before intervention. Results At diagnosis, significantly decreased (52% control levels) increased AN (164% levels). After intervention, patients but without reaching even body mass index (BMI). In AN, normalized increase BMI. Ghrelin correlated negatively positively IGFBP-1 controls not diagnosis. The positive between was recovered Conclusions Plasma present opposite changes obesity suggesting that is good marker nutritional status.
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