Antidepressant treatment of the depressed patient with insomnia.

摘要: Sleep disturbances are an integral part of depressive disorder. As such, they a all contemporary sets diagnostic criteria for major depression and symptom-based rating scales depression. Insomnia is particularly frequent complaint, it reported by more than 90% depressed patients. Although the kindling or illness transduction model remains hypothetical, there evidence that people with recurrent have pronounced abnormalities sleep neurophysiology those experiencing single initial episode. Therefore, early relief insomnia in patient, addition to alleviating other symptoms, may increase adherence treatment daytime performance overall functioning, while complete improve prognosis. Stimulation serotonin-2 (5-HT 2 ) receptors thought underlie changes architecture seen selective serotonin reuptake inhibitors (SSRIs) serotonin-norepinephrine (SNRIs). This reason why hypnotics low-dose trazodone commonly coprescribed at initiation either SSRIs SNRIs. On hand, antidepressant drugs 5-HT blocking properties, such as mirtazapine nefazodone, alleviate architecture. In patients, produces significant shortening sleep-onset latency, increases total time, leads marked improvement efficiency. Antidepressants preferential proper ties therefore good option patients insomnia.