A meta analysis of cetuximab plus oxaliplatin based chemotherapy regimen for metastatic colorectal cancer.

摘要: Background: Oxaliplatin based chemotherapy regimen was one of the most used modality for metastatic colorectal cancer. The purpose this meta-analysis to assess clinical activity and toxicities cetuximab plus oxaliplatin-based Cancer. Methods: We searched studies about versus alone cancer in databases PubMed, EMBASE, Cochran, CNKI. data response were extracted pooled by random or fixed effects model. And publication bias evaluated begg's funnel plot egger's regression test. Results: Seven papers included study. Adding regime can significant increase rate K-RAS mutation patients (odds ratio [OR]: 1.45, 95% confidence interval [CI]: 1.17-1.80, Z = 3.38, P 0.001) without knowing status (OR: 1.36, CI: 1.11-1.65, 1.89, 0.003). But with mutated K-RAS, improvement objective not statistical 0.70, 0.49-1.01, 3.00, 0.058) when adding regime. results indicating rash diarrhea risk significantly increased combined treatment group ( > 0.05). Significant found evaluation. Conclusion: Cetuximab some such also increased.