Visible-Light-Driven, One-pot Amide Synthesis Catalyzed by the B12 Model Complex under Aerobic Conditions.

摘要: A visible light responsive catalytic system with the B12 complex as catalyst and [Ir(dtbbpy)(ppy)2 ]PF6 photosensitizer was developed. It provides a convenient efficient way to synthesize amides. Based on this method, trichlorinated organic compounds were converted into amides in presence of an amine under aerobic conditions at room temperature one-pot procedure. Various source, such primary, secondary, cyclic amines, have been evaluated for transformation, providing expected products moderate excellent yields. Notably, product formation depended reaction atmosphere where amide obtained while partially dechlorinated anaerobic conditions. As protocol is free from hazardous reagents, extra additives, noble metals, dangerous gas, present method novel approach synthesis mild easily controlled