Oncogenic gene fusions in epithelial carcinomas

摘要: New discoveries regarding recurrent chromosomal aberrations in epithelial tumors have challenged the view that gene fusions play a minor role these cancers. It is now known characterize significant subsets of prostate, breast, lung and renal-cell carcinomas, among others. This work has generated new insights into molecular subtypes highlighted important advances bioinformatics, sequencing, microarray technology as tools for fusion discovery. Given ubiquity tyrosine kinases transcription factors fusions, further interest potential 'druggability' with targeted therapeutics also flourished. Nevertheless, majority abnormalities cancers remain uncharacterized, underscoring limitations our knowledge carcinogenesis requirement research.