[Association of polymorphism for HLA-DQA1 promotor region (QAP) with IDDM].

摘要: We have identified the DNA polymorphism for HLA-DQA1 promotor region (QAP) in patients with early and late onset insulin-dependent diabetes mellitus (IDDM) by PCR direct sequencing. The result showed that single nucleotide substitution at position-92(C-->T-92) -146 (T-->C-146) were detected QAP IDDM respectively. These findings suggests mutation seems to alter conformation of so these are likely influence aberrant expression MHC-class II loci beta-pancreatic islet cells.