Increased leptin levels correlate with thyroid autoantibodies in nonobese males.

摘要: Summary Objective Leptin is an adipokine that regulates body weight and appetite. It also inflammatory cytokine influences immune reactivity autoimmunity. levels are increased in obesity higher women than men. We aimed to determine whether leptin levels, independent of sex mass index (BMI), associated with thyroid Design This study uses data from The Third National Health Nutrition Examination Survey (NHANES III) test the association autoimmunity, BMI. Measurements Thyroid-stimulating hormone, thyroxine, antithyroid peroxidase (TPO) antibodies were measured 2902 men 3280 within NHANES III population. BMI was calculated height weight. Results Women had significantly antiTPO antibody titres Correlation analyses demonstrated anti-TPO total population, but when analysed separately, this lost. then stratified into obese (BMI > 30) or nonobese ≤ subgroups determined between for each subgroup. Using regression analysis, we found correlated autoantibodies males, not males females. Conclusions autoantibody males. Sex habitus should therefore be considered studying role other autoimmune conditions.