A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.

摘要: Abstract We studied the expression of two vertebrate homeobox genes, Otx1 and Otx2, related to orthodenticle, a gene expressed in developing head Drosophila. Both genes are restricted regions rostral brain including presumptive cerebral cortex olfactory bulbs. The patterns diencephalon suggest that they both have role establishing boundary between dorsal ventral thalamus. They also olfactory, auricolar ocular system, covering optic nerve. is detectable from day 8 gestation telencephalic, diencephalic mesencephalic regions. From 10.5 its extends some metencephalic areas. Otx2 appears be already epiblast prestreak embryos. It persists entire embryonic ectoderm for time after onset gastrulation. In midstreak embryos progressively anterior corresponding fore- mid-brain. early midgestation it but 11.75 disappears telencephalon confined one earliest immediately afterwards neuroectoderm, demarcating even before headfold formation. Its product contains homeodomain bicoid class able recognize transactivate target sequence.