Predictors of loss of hepatitis B surface antigen in HIV-infected patients

摘要: AIM: To study factors associated with loss of hepatitis B surface antigen (HBsAg) in patients co-infected human immunodeficiency virus (HIV) and (HBV). METHODS: We retrospectively reviewed the medical records 5681 followed up at two New York City HIV clinics from January 1999 to May 2007. Clinical laboratory parameters including baseline follow-up viral loads, CD4 cell counts, alanine transaminase levels, demographics, presence C infection, treatment highly active antiretroviral therapy dually against both HBV were analyzed determine HBsAg. RESULTS: Three hundred fifty five (355/5681, 6.84%) evaluated. Of these, 226 more than 12 mo included further analysis HBsAg long-term follow-up. In univariate analysis, count was (P = 0.052). Cox regression revealed that > 500 cells/mm3 0.016, odds ratio: 76.174, 95% confidence interval: 2.233-2598.481). CONCLUSION: Our showed an interesting association HIV-HBV higher count, suggesting T-cell cytolytic activity may still be effective clearing infection.