Investigating the role of the corpus callosum in regulating motor overflow in multiple sclerosis.

摘要: The corpus callosum (CC) is commonly affected in multiple sclerosis (MS), however, sensitive behavioral measures of MS-related CC pathology are lacking. considered a key structure the mediation type involuntary movement known as motor overflow. In this study, we sought to characterize impact damage on overflow MS. Twenty MS participants and 20 controls performed unilateral force production task. Motor (involuntary force) non-active hand was measured while active volume lesion load were calculated for using T2-weighted MRI. We found no group differences overflow; correlated significantly with disease severity [Expanded disability status scale (EDSS)]. (lesions decreased volume) did not correlate This study suggests that may directly lead changes regulation Rather, findings support notion wider network structures mediate suppression