Maternal obesity regulates gene expression in the hearts of offspring.

摘要: Background and aims: Growing evidence suggests maternal obesity leads to adverse outcomes for offspring, including increased cardiovascular disease (CVD). Alterations in taste preferences of offspring from mothers consuming a high fat diet (HFD) have also been reported. Given recent reports describing cardiac receptors, we examined whether the expression umami bitter receptors is modulated by obesity, compared this with physiological challenge exercise. Methods results: Female Sprague-Dawley rats were fed chow (C) or HFD (F) half each provided running wheel enable voluntary exercise (CE FE), others remain- ing sedentary (CS FS). Two pups mother killed at postnatal day 19. Both lean obese dams undertook similar amounts (8.1 � 2.4 vs 5.1 1.5 km). Maternal body weight, adiposity, net weight-corrected heart ventricle no effect plasma lep- tin concentrations, which normalised Cardiac mRNA expres- sion b-adrenoceptor (Adrbk1) angiotensin II receptor type 1a (Agtr1a) significantly decreased response decreasing Agtr1a FE offspring. No changes observed. FTO was down-regulated an up-regulation CE mothers. Conclusion: affected other genes ventricle, potentially implicating these development CVD associated