A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune Disease
作者： Ehsanollah Esfandiari , Iain B. McInnes , George Lindop , Fang-Ping Huang , Max Field
DOI: 10.4049/JIMMUNOL.167.9.5338
关键词:
摘要: Serum from patients with systemic lupus erythematosus (SLE) contained significantly higher concentrations of IL-18 than normal individuals. MRL/lpr mice, which develop spontaneous lupus-like autoimmune disease, also had serum levels wild-type MRL/++ mice. Daily injections or plus IL-12 resulted in accelerated proteinuria, glomerulonephritis, vasculitis, and raised proinflammatory cytokines IL-18-treated mice developed a "butterfly" facial rash resembling clinical SLE. In contrast, treated did not rash. The lesion the showed epidermal thickening intense chronic inflammation accompanied by increased apoptosis, Ig deposition, early Th2 response compared control These data therefore show that is an important mediator disease may thus be novel target for therapeutic intervention diseases.
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Giamila Fantuzzi, Adrian J. Puren, Matthew W. Harding, David J. Livingston, Charles A. Dinarello, Interleukin-18 Regulation of Interferon γ Production and Cell Proliferation as Shown in Interleukin-1β–Converting Enzyme (Caspase-1)-Deficient Mice Blood. ,vol. 91, pp. 2118- 2125 ,(1998) , 10.1182/BLOOD.V91.6.2118
Francesco Trapasso, Tiziana Parrello, Livia Biancone, Rodolfo Iuliano, Giovanni Monteleone, Alfredo Fusco, Antonella Stella, Francesco Luzza, Francesco Pallone, Bioactive IL-18 expression is up-regulated in Crohn's disease. Journal of Immunology. ,vol. 163, pp. 143- 147 ,(1999)
S L Peng, J Craft, S Fatenejad, Induction of nonpathologic, humoral autoimmunity in lupus-prone mice by a class II-restricted, transgenic alpha beta T cell. Separation of autoantigen-specific and -nonspecific help. Journal of Immunology. ,vol. 157, pp. 5225- 5230 ,(1996)
J Kataoka, K Kohno, M Kurimoto, M Ikeda, M Usui, I Okamoto, Y Suemoto, T Ohtsuki, IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. Journal of Immunology. ,vol. 158, pp. 1541- 1550 ,(1997)
D Wofsy, P S Linsley, D I Daikh, D Hollenbaugh, B K Finck, Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways. Journal of Immunology. ,vol. 159, pp. 3104- 3108 ,(1997)
Kei-ichi Yamanaka, Minoru Tanaka, Hiroko Tsutsui, Thomas S. Kupper, Kunihiko Asahi, Haruki Okamura, Kenji Nakanishi, Misao Suzuki, Nobuhiko Kayagaki, Roy A. Black, Douglas K. Miller, Kunio Nakashima, Masayuki Shimizu, Hitoshi Mizutani, Skin-Specific Caspase-1-Transgenic Mice Show Cutaneous Apoptosis and Pre-Endotoxin Shock Condition with a High Serum Level of IL-18 The Journal of Immunology. ,vol. 165, pp. 997- 1003 ,(2000) , 10.4049/JIMMUNOL.165.2.997
Mark J Walport, Lupus, DNase and defective disposal of cellular debris Nature Genetics. ,vol. 25, pp. 135- 136 ,(2000) , 10.1038/75963
Tsaiwei Olee, Martin Lotz, Sanshiro Hashimoto, Jacqueline Quach, IL-18 Is Produced by Articular Chondrocytes and Induces Proinflammatory and Catabolic Responses Journal of Immunology. ,vol. 162, pp. 1096- 1100 ,(1999)
Shuji Nakamura, Takeshi Otani, Yoshihiro Ijiri, Ryuichi Motoda, Masashi Kurimoto, Kunzo Orita, IFN-γ-Dependent and -Independent Mechanisms in Adverse Effects Caused by Concomitant Administration of IL-18 and IL-12 The Journal of Immunology. ,vol. 164, pp. 3330- 3336 ,(2000) , 10.4049/JIMMUNOL.164.6.3330
Hiroshi Takayanagi, Kouetsu Ogasawara, Shigeaki Hida, Tomoki Chiba, Shigeo Murata, Kojiro Sato, Akinori Takaoka, Taeko Yokochi, Hiromi Oda, Keiji Tanaka, Kozo Nakamura, Tadatsugu Taniguchi, T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature. ,vol. 408, pp. 600- 605 ,(2000) , 10.1038/35046102