Hyaluronic acid for anticancer drug and nucleic acid delivery.

作者: Franco Dosio , Silvia Arpicco , Barbara Stella , Elias Fattal

DOI: 10.1016/J.ADDR.2015.11.011

关键词:

摘要: Hyaluronic acid (HA) is widely used in anticancer drug delivery, since it is biocompatible, biodegradable, non-toxic, and non-immunogenic; moreover, HA receptors are overexpressed on many tumor cells. Exploiting this ligand-receptor interaction, the use of HA is now a rapidly-growing platform for targeting CD44-overexpressing cells, to improve anticancer therapies. The rationale underlying approaches, chemical strategies, and recent advances in the use of HA to design drug carriers for delivering anticancer agents, are …

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