摘要: We appreciate the thoughtful comments and concerns of Giovino, who was intimately involved in Institute Medicine’s (IOM’s) assessment scientific basis for tobacco harm reduction. did not state, nor we intend to imply, that IOM report primarily about less hazardous cigarettes. Further, took care describe as “endorsing reduction only ‘as a component comprehensive national control program emphasizes abstinence-oriented prevention treatment.’ ” We recognize term “safer cigarette” is problematic. But our purpose article analyze historical evolution public health thinking “safer” products. The belief such products were possible central history, use cigarettes.” We believe others who, like us, are interested how broadly community defines coming years what place will occupy within framework appropriately read stating need face squarely challenge tobacco-based