Effect of lercanidipine on kidney microanatomy in Cohen-Rosenthal diabetic hypertensive rats.

摘要: The study was undertaken to determine the effect of treatment with dihydropyridine-type calcium antagonist lercanidipine on renal vasculature in Cohen-Rosenthal diabetic hypertensive rats, a genetic model hypertension associated type 2 diabetes mellitus. Eight animals were given daily oral dose 3 mg/kg drinking water for 8 weeks, and 6 control received no treatment. effects blood pressure, glucose level, kidney microanatomy evaluated. Lercanidipine reduced systolic pressure level. In group small arteries glomerular arterioles exhibited wall thickening luminal narrowing. administration prevented changes small-sized arterioles. observed untreated rats not seen lercanidipine-treated animals. also had beneficial vasculature, suggesting that compound may be considered treating diabetes.