Prevention of diabetes and prolongation of the honeymoon phase of diabetes by administration of GnRH antagonists

摘要: A method for reducing the incidence or delaying onset of diabetes in diabetes-susceptible mammals (e.g., mice, rats, humans) is provided wherein are treated with a gonadotropin-releasing hormone (GnRH) antagonist. Additionally, present invention provides prolonging honeymoon phase and decreasing rate islet cell infiltration by lymphocytes administration GnRH Preferably, antagonist administered repeatedly over time subcutaneous injection. Preferred antagonists include Acetyl-β-[2-Naphthyl]-D-Ala-D-p-Chloro-Phe-β-[3-Pyridyl]-D-Ala-Ser-Ne-[Nicotinoyl]-Lys-Ne-[Nicotinoyl]-D-Lys-Leu-Ne-[Isopropyl]-Lys-Pro-D-Ala-NH 2 , Nal-Glu, Abarelix, Degarelix, acetyl-D2Nal-D4CIPhe-D3Pal-Ser-Aph(Ac)-D-Aph(Ac)-Leu-Lys(lpr)-Pro-D-Ala-NH2.