Phagocytosis and macropinocytosis in Dictyostelium: phosphoinositide-based processes, biochemically distinct.

摘要: Phagocytosis and macropinocytosis are actin-dependent clathrin-independent processes primarily performed by cells like neutrophils macrophages that result in the internalization of particles or formation fluid-filled macropinosomes, respectively. consists a number stages, including attachment to cell surface receptors, engulfment particle dependent on actin polymerization membrane exocytosis, phago-lysosomes. In contrast, molecular steps regulating only just now being deciphered. Much remains be learned concerning signaling pathways regulate these processes. Dictyostelium is genetically biochemically tractable professional phagocyte has proven powerful system with which determine nature involved This review summarizes what currently understood mechanisms governing phagocytosis describes recent data common distinct