Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

摘要: We have cloned and characterized the mouse homolog of human trk proto-oncogene, a member protein tyrosine kinase (TK) receptor gene family. Here, we present first report trk-encoded mRNA species in vivo. In situ hybridization analysis embryo reveals striking temporal spatial regulation transcription, with expression confined to sensory cranial (trigeminal, superior, jugular) dorsal root ganglia (DRG) neural crest origin. Recent reports shown that TK receptors can play regulatory roles embryonic development. Thus, developmental mutations W torso sevenless Drosophila represent genes code for defective receptors. Our data show trk, associated malignancy humans, is specific marker set crest-derived neurons, are consistent hypothesis this protoooncogene may an important role development or phenotype neurons where it expressed.