Diagnostic and therapeutic approach to drug-resistant juvenile myoclonic epilepsy.
作者： Edoardo Ferlazzo , Edoardo Ferlazzo , Umberto Aguglia , Umberto Aguglia , Vittoria Cianci
DOI: 10.1080/14737175.2021.1931126
关键词:
摘要: Introduction Juvenile myoclonic epilepsy (JME), also known as Janz syndrome, is a common form of generalized presumed genetic origin representing up to 10% all cases. Despite adequate anti-seizure medication (ASM) treatment, seizures persist in one-third JME patients. Areas covered A literature search was conducted using Pubmed on the topics drug-resistant JME. Expert opinion About 30% patients are drug-resistant. Valproate (VPA) considered first-choice drug. In women childbearing potential, levetiracetam (LEV) should represent treatment. Alternative monotherapy or add-on therapy be subjects with resistant after exclusion pseudo-drug resistance. The choice ASM depends predominant seizure type. persistent bilateral tonic-clonic seizures, LEV lamotrigine firstly considered. difficult-to-treat clonazepam recommended. case absences, ethosuximide With appropriate selection and safeguards place, VPA remain available an option potential whose other treatments.
sci-hub.st 参考文章(93)
Delanty N, Doherty C, Flynn C, O'Rourke D, White M, Potential efficacy of zonisamide in refractory juvenile myoclonic epilepsy: retrospective evidence from an Irish compassionate-use case series. Irish Medical Journal. ,vol. 100, pp. 431- ,(2007)
Reetta Kälviäinen, Progressive Myoclonus Epilepsies. Seminars in Neurology. ,vol. 35, pp. 293- 299 ,(2015) , 10.1055/S-0035-1552620
Eugen Trinka, Gudrun Kienpointner, Iris Unterberger, Gerhard Luef, Gerhard Bauer, Lisa Bartha Doering, Stephan Doering, Psychiatric comorbidity in juvenile myoclonic epilepsy. Epilepsia. ,vol. 47, pp. 2086- 2091 ,(2006) , 10.1111/J.1528-1167.2006.00828.X
Udaya Seneviratne, Mark Cook, Wendyl D’Souza, The prognosis of idiopathic generalized epilepsy. Epilepsia. ,vol. 53, pp. 2079- 2090 ,(2012) , 10.1111/J.1528-1167.2012.03723.X
Ji Hyun Kim, Sang-il Suh, So-Yeon Park, Woo-Keun Seo, InSong Koh, Seong-Beom Koh, Hae Young Seol, Microstructural white matter abnormality and frontal cognitive dysfunctions in juvenile myoclonic epilepsy Epilepsia. ,vol. 53, pp. 1371- 1378 ,(2012) , 10.1111/J.1528-1167.2012.03544.X
Serge Vulliemoz, Christian Vollmar, Matthias J. Koepp, Mahinda Yogarajah, Jonathan O’Muircheartaigh, David W. Carmichael, Jason Stretton, Mark P. Richardson, Mark R. Symms, John S. Duncan, Connectivity of the supplementary motor area in juvenile myoclonic epilepsy and frontal lobe epilepsy Epilepsia. ,vol. 52, pp. 507- 514 ,(2011) , 10.1111/J.1528-1167.2010.02770.X
Christof Kessler, Uwe Runge, Julia Geithner, Felix Schneider, Zhong Wang, Julia Berneiser, Rosemarie Herzer, Predictors for long-term seizure outcome in juvenile myoclonic epilepsy: 25-63 years of follow-up Epilepsia. ,vol. 53, pp. 1379- 1386 ,(2012) , 10.1111/J.1528-1167.2012.03526.X
Ainhoa Marinas, Vicente Villanueva, Beatriz G Giráldez, Albert Molins, Javier Salas-Puig, Jose M Serratosa, Efficacy and tolerability of zonisamide in idiopathic generalized epilepsy Epileptic Disorders. ,vol. 11, pp. 061- 066 ,(2009) , 10.1684/EPD.2009.0239
Jacqueline A. French, Gregory L. Krauss, Robert T. Wechsler, Xue-Feng Wang, Bree DiVentura, Christian Brandt, Eugen Trinka, Terence J. O'Brien, Antonio Laurenza, Anna Patten, Francesco Bibbiani, Perampanel for tonic-clonic seizures in idiopathic generalized epilepsy A randomized trial Neurology. ,vol. 85, pp. 950- 957 ,(2015) , 10.1212/WNL.0000000000001930
Huntley Hardison, Agustin Legido, Sanjeev V Kothare, Ignacio Valencia, Joseph J Melvin, Divya S Khurana, Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy Epileptic Disorders. ,vol. 6, pp. 267- 270 ,(2004)