A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17β‐trenbolone

摘要: Trenbolone acetate is widely used in some parts of the world for its desirable anabolic effects on livestock. Several metabolites acetate, including 17β-trenbolone, have been detected at low nanograms per liter concentrations surface waters associated with animal feedlots. The 17β-trenbolone isomer can affect androgen receptor signaling pathways various vertebrate species comparatively concentrations/doses. present article provides a comprehensive review and synthesis existing literature concerning exposure to biological an emphasis potential risks aquatic animals. In vitro studies indicate that, although activate several nuclear hormone receptors, highest affinity all taxa examined, fish. Exposure fish water cause changes endocrine function short term, adverse apical longer exposures during development reproduction. Impacts typically are indicative inappropriate signaling, such as sex steroid metabolism, impacts gonadal stage, masculinization females. sexual differentiation early greatly skew ratios, whereas adult adversely impact fertility fecundity. To fully assess ecosystem-level risks, additional research warranted address uncertainties degree/breadth environmental population-level sensitive species. Environ Toxicol Chem 2018;37:2064-2078. Published 2018 Wiley Periodicals Inc. behalf SETAC. This US government work and, such, public domain United States America.