Inhibitors of purified beef adrenal tyrosine hydroxylase.
作者： Sidney Udenfriend , P. Zaltzman-Nirenberg , T. Nagatsu
DOI: 10.1016/0006-2952(65)90103-6
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摘要: Abstract Two classes of compounds have been investigated as inhibitors purified beef adrenal tyrosine hydroxylase. Among the aromatic amino acids analogues were found to be most potent, particularly those having an α-methyl or 3-halogen substitution. normal metabolites, mono- and diiodo-tyrosine, very effective inhibitors. Inhibition by acid was shown competitive with substrate. Catechols also inhibitory, 3,4-dihydroxy-phenylpropylacetamide (compound H 22/54). latter reversed cofactor (tetrahydrofolate DMPH 4 ) but not tyrosine.
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