The multiple roles of guanylate cyclase C, a heat stable enterotoxin receptor.

摘要: Purpose of review Guanylate cyclase C (GC-C) is a transmembrane receptor that expressed primarily on intestinal epithelial cells. Activation this by its endogenous peptide ligands initiates cyclic guanosine monophosphate-dependent (cGMP) salt and water movement in the intestine. GC-C targeted enterotoxigenic Escherichia coli heat-stable enterotoxin STa, which deregulates pathway causes secretory diarrhea. This discusses current work physiological function Recent findings Familial mutations demonstrate cGMP signaling critical to electrolyte fluid balance neonatal Chronic deregulation activity early life increases susceptibility number disorders, including obstruction inflammatory bowel disease. Murine models indicate regulates composition commensal microflora it suppresses bacterial infection modulates colonic injury inflammation. Therapeutic are used successfully treat constipation-predominant irritable syndrome recent studies show extracellular an important mechanism reducing abdominal pain associated with disorder. Summary Originally identified as target E. regulator homeostasis may directly impact wide range disorders.