Signalling through phosphoinositide 3-kinases: the lipids take centre stage.
作者： Sally J Leevers , Bart Vanhaesebroeck , Michael D Waterfield
DOI: 10.1016/S0955-0674(99)80029-5
关键词:
摘要: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids at the 3' position of ring to generate 3-phosphoinositides PI(3)P, PI(3,4) P2 and PI(3,4,5) P3. Recent research has shown that one way in which these function signal transduction membrane trafficking is by interacting with 3-phosphoinositide-binding modules a broad variety proteins. Specifically, certain FYVE domains bind PI(3)P whereas pleckstrin homology and/or Also 1998, PTEN - major tumour suppressor human cancer was also antagonise PI3K signalling removing 3-phosphate from 3-phosphoinositides.
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