Blood-brain barrier function and it’s relation to dementia development (651.8)

摘要: Our aim was to further investigate the relation BBB and developing of dementia. We investigated blood-brain barrier (BBB) function by measuring cerebrospinal fluid (CSF,) mg/l, in serum albumin (g/L) ratio (CSF/S-albumin x 10-3) a population-based sample 85-year-olds. Sixty-five underwent lumbar punctured (LP) at age 85-year, CSF-albumin, -β -amyloid -Tau. Fifty-three them also Computed Tomography CT. The participants were then followed up until death. Repeated studies (e.g. 88, 90, 95, 97, 100 for survivors, cases possible, every year death) conducted search dementia signs. Several previous CSF (1,2, 3, 4), but not all (5, 6, 7), reported dysfunction AD. Decreased mitochondrial content increased pinocytotic vesicles capillary endothelium AD patients (8) support that may be involved pathogenesis (9, 10, 11, 12, 13). secondary A...