Endectocides in goats: Pharmacology, efficacy and use conditions in the context of anthelmintics resistance

摘要: Endectocides (avermectins/mibemycins) are today one of the most important anthelmintic families for control in livestock nematodes and their use is increasing goats because high frequency benzimidazole resistance. Goat has specific pharmacological parameters endectocides compared to sheep or cattle (absorption elimination). The behaviour drug organism, represented by pharmacokinetic parameters, affected through several ways including route administration formulation, host animal (nutrition, parasitism, physiological status, amount fat tissue). For each species, determination dose rates needed insure an optimal activity against (particularly those inhabiting small intestine). This scientific knowledge a prerequisite better different goats. An objective chemical define best deworming practices that reduce risk nematode resistance occurrence decrease selection pressure on populations. main points rational anthelmintics include rate, administration, annual period treatment, alternative selective treatment excreting animals.