The Evolution of Immunosuppressive Cell Populations in Experimental Mycobacterial Infection

摘要: Immunosuppressor activity of considerable potency and complexity was generated during the course chronic, progressive infection C3H/Anf mice by Mycobacterium lepraemurium. From 5th through 10th week after inoculation, spleen cells from infected mildly but reproducibly suppressed direct plaque-forming cell response normal cultures to sheep erythrocytes. Suppression at this stage mediated with macrophage-like characteristics. A marked increase in splenic suppressor 10 11 weeks associated appearance a second subpopulation composed T lymphocytes. The these closely related time onset rapid enlargement loss cutaneous delayed type hypersensitivity antigens M. lepraemurium infection. Suppressor were not present peripheral lymph nodes until terminal 22 25 weeks. depressed T-dependent antibody most severely, there also effect upon B as shown moderate suppression responses TNP-LPS DNP-Ficoll. Spleen 14-week-infected soluble factor(s) that induces depression severity, however, immunosuppression intact far greater.