The Effects of Inflammation, Infection and Antibiotics on the Microbiota-Gut-Brain Axis

摘要: Animal studies have demonstrated that the early phase of enteric infection is accompanied by anxiety-like behavior, which mediated through vagal ascending pathways. Chronic alters gut function, including motility and visceral sensitivity, as well feeding patterns, anxiety depression-like behavior. These effects are likely immune-mediated, involve changes in pro-inflammatory cytokines altered metabolism kynurenine/tryptophan Clinical shown chronic gastrointestinal infections lead to malnutrition stunting, resulting impaired cognitive function. Accumulating evidence suggests addition pathogens, commensal microbiota also influences function host’s Both animal clinical behavior brain chemistry after induction intestinal dysbiosis administration antibiotics. This concept microbiota-gut-brain interactions opens a new field research aimed at developing microbial-directed therapies treat broad spectrum human conditions, psychiatric disorders.