Refinements in mathematical models to predict aneurysm growth and rupture.

作者: R. BERGUER , J. L BULL , K. KHANAFER

DOI: 10.1196/ANNALS.1383.033

关键词:

摘要: The growth of aneurysms and eventually their likelihood rupture depend on the determination stress strain within aneurysm wall exact reproduction its geometry. A numerical model is developed to analyze pulsatile flow in abdominal aortic (AAA) models using real physiological resting exercise waveforms. Both laminar turbulent flows are considered. Interesting features field resulting from realistic waveforms obtained for various parameters finite element methods. Such include Reynolds number, size (D/d), flexibility wall. effect non-Newtonian behavior blood hemodynamic stresses compared with Newtonian behavior, effects demonstrated be significant situations. Our results show that maximum fluid shear occurs at distal end AAA model. Furthermore, turbulence found have a pressure distribution along both Related experimental work which bench top also discussed. provides platform validate This part our ongoing development patient-specific tool guide clinician decision making elucidate contribution flow-induced eventual rupture. These studies indicate accurately modeling physiologic paramount achieving goal.

参考文章(7)
Reid M. Wainess, Justin B. Dimick, John A. Cowan, Peter K. Henke, James C. Stanley, Gilbert R. Upchurch, Epidemiology of surgically treated abdominal aortic aneurysms in the United States, 1988 to 2000. Vascular. ,vol. 12, pp. 218- 224 ,(2004) , 10.1258/RSMVASC.12.4.218
Charles L. Asbury, Jeffrey W. Ruberti, Edward I. Bluth, Robert A. Peattie, Experimental investigation of steady flow in rigid models of abdominal aortic aneurysms. Annals of Biomedical Engineering. ,vol. 23, pp. 29- 39 ,(1995) , 10.1007/BF02368298
R. Budwig, D. Elger, H. Hooper, J. Slippy, Steady flow in abdominal aortic aneurysm models. Journal of Biomechanical Engineering-transactions of The Asme. ,vol. 115, pp. 418- 423 ,(1993) , 10.1115/1.2895506
C. J. Mills, I. T. Gabe, J. H. Gault, D. T. Mason, J. Ross, E. Braunwald, J. P. Shillingford, Pressure-flow relationships and vascular impedance in man Cardiovascular Research. ,vol. 4, pp. 405- 417 ,(1970) , 10.1093/CVR/4.4.405
Erik Morre Pedersen, Hsing-Wen Sung, Armelle Cagniot Burlson, Ajit P. Yoganathan, Two-dimensional velocity measurements in a pulsatile flow model of the normal abdominal aorta simulating different hemodynamic conditions Journal of Biomechanics. ,vol. 26, pp. 1237- 1247 ,(1993) , 10.1016/0021-9290(93)90071-L
Momtaz Wassef, B.Timothy Baxter, Rex L. Chisholm, Ronald L. Dalman, Mark F. Fillinger, Jay Heinecke, Jay D. Humphrey, Helena Kuivaniemi, William C. Parks, William H. Pearce, Christopher D. Platsoucas, Galina K. Sukhova, Robert W. Thompson, M.David Tilson, Christopher K. Zarins, Pathogenesis of abdominal aortic aneurysms: A multidisciplinary research program supported by the National Heart, Lung, and Blood Institute****** Journal of Vascular Surgery. ,vol. 34, pp. 730- 738 ,(2001) , 10.1067/MVA.2001.116966
Takayoshi Fukushima, Teruo Matsuzawa, Tatsuji Homma, Visualization and finite element analysis of pulsatile flow in models of the abdominal aortic aneurysm. Biorheology. ,vol. 26, pp. 109- 130 ,(1989) , 10.3233/BIR-1989-26203