Intake of dietary folate vitamers and risk of colorectal carcinoma: results from The Netherlands Cohort Study.
作者： Erik JM Konings , R Alexandra Goldbohm , Henny AM Brants , Wim HM Saris , Piet A van den Brandt
DOI: 10.1002/CNCR.10866
关键词:
摘要: BACKGROUND. Several studies have reported inverse associations between folate intake and colorectal carcinoma risk. Few were prospective none evaluated the association of individual vitamers METHODS. The aim current study was to investigate relationship dietary risk in a large cohort Netherlands comprising 120,852 men women aged 55-69 years. After 7.3 years follow-up, 760 colon 411 rectal cases available for analysis. Data processing analysis used case-cohort approach. A new Dutch database estimate intakes total vitamers. RESULTS. Analyses adjusted age, energy intake, family history carcinoma, alcohol, vitamin C, iron, fiber yielded an (rate ratio [RR]highest vs. lowest quintile, men: 0.73; 95% confidence interval [CI], 0.46-1.17, P trend = 0.03; women: 0.68; CI, 0.39-1.20, 0.18). An found only among (RR highest 0.66; 0.35-1.21, 0.03). showed no clear difference associated with different CONCLUSIONS. Dietary related inversely male © 2002 American Cancer Society. Chemicals/CAS: Folic Acid, 59-30-3; Hematinics
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