Small nucleolar RNA 78 promotes the tumorigenesis in non-small cell lung cancer

摘要: Accumulating evidence suggests that dysregulated snoRNA may play a role in the development of malignancy. In present study, we investigated SNORD78 tumorigenesis non-small cell lung cancer (NSCLC). We determined expression level NSCLC tissues with quantitative real-time PCR and then studied its clinical significance. explored biological significance gain-and-loss-of-function analyses both vitro vivo. A great upregulation was observed compared to their adjacent normal tissues. Meanwhile, patients high have significantly poorer prognosis than those low expression. Inhibition suppressed proliferation cells via inducing G0/G1 cycle arrest apoptosis while overexpression promoted proliferation. invasion epithelial-mesenchymal-transition (EMT). also obviously upregulated stem-like is required for self-renewal NSCLC. The oncogenic activity confirmed vivo data. Our study identified be potential therapeutic target