Ambulatory blood pressure monitoring in the evaluation of antihypertensive treatment: additional information from a large data base

摘要: Aims of our study were i) to compare in a large number hypertensive subjects the relative effect antihypertensive treatment on clinic (C) blood pressure (BP) and various ambulatory (A) BP components, ii) determine whether affects variability. In 266 mild essential outpatients (age: 18-78 years) CBP (trough measurements) ABP (Spacelabs 90202 or 90207) measured after 3 4 weeks wash-out 8 with an ACE-inhibitor (n = 135) calcium-antagonist 131). recordings analyzed obtain average 24 h, day-time (6 a.m. midnight) night-time (midnight 6 a.m.) systolic diastolic values standard deviations (BP variabilities). Treatment reduced both ABP. Treatment-induced changes showed poor correlation those 24h, day- (r never > 0.23) was also when trough (mean last 2 h) considered. Twenty-four hour, similarly by direct relationship between initial subsequent falls. relation pretreatment but overall reduction small, limited proportional less than mean values, no increase variation coefficients. The effects treatments superimposable. Our results from data base show that effectively reduces all components. cannot be predicted concomitant fall it relates values. has variability, this being case for ACE-inhibitors calcium-antagonists.