Environmental nanoparticles, SARS-CoV-2 brain involvement, and potential acceleration of Alzheimer's and Parkinson's diseases in young urbanites exposed to air pollution

摘要: Alzheimer's and Parkinson's diseases (AD, PD) have a pediatric young adult onset in Metropolitan Mexico City (MMC) The SARS-CoV-2 neurotropic RNA virus is triggering neurological complications deep concern regarding acceleration of neuroinflammatory neurodegenerative processes already progress This review, based on our MMC experience, will discuss two major issues: 1) why residents chronically exposed to air pollution are likely be more susceptible systemic brain effects 2) people with AD PD accelerate Secondary mental consequences social distancing isolation, fear, financial insecurity, violence, poor health support, lack understanding the complex crisis expected infected or free pre-SARS-CoV-2 accumulation misfolded proteins diagnostic metal-rich, magnetic nanoparticles damaging key neural organelles an ideal host for invading body through same portals damaged by nanoparticles: nasal olfactory epithelium, gastrointestinal tract, alveolar-capillary portal We urgently need multicenter retrospective-prospective psychiatric population follow-up intervention strategies place case processes, increased risk suicide, disease worsening Identification vulnerable populations continuous effort lower ought critical steps © 2021 authors IOS Press All rights reserved