Controlled release of angiogenic growth factors from poly(lactic -co -glycolic acid) implants for therapeutic angiogenesis
作者： Li Zhang
DOI:
关键词:
摘要: xvii CHAPTER 1: INTRODUCTION 1 1.1 Cardiovascular disease (CVD) 1.2 Neovascularization 2 1.3 Molecular and cellular regulation of angiogenesis 4 1.3.1 Hypoxia-inducible factor-1 (HIF-1) 5 1.3.2 Inflammation 6 1.3.3 VEGF in 8 1.3.4 bFGF 10 1.3.5 Ang2 Tie 11 1.3.6 PDGF 12 1.3.7 Synergy growth factors 13 1.4 Animal models 14 1.4.1 myocardial ischemia 15 1.4.2 hind limb 18 1.5 Clinical trials 1.5.1 using recombinant proteins 19 1.5.2 gene therapy 20 1.5.3 cell 26 1.5.4 Assessment therapeutics 1.6 Differences between preclinical clinical studies 27
参考文章(252)
E. Tischer, R. Mitchell, T. Hartman, M. Silva, D. Gospodarowicz, J.C. Fiddes, J.A. Abraham, The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. Journal of Biological Chemistry. ,vol. 266, pp. 11947- 11954 ,(1991) , 10.1016/S0021-9258(18)99049-6
J.C. Lee, S.N. Timasheff, The stabilization of proteins by sucrose. Journal of Biological Chemistry. ,vol. 256, pp. 7193- 7201 ,(1981) , 10.1016/S0021-9258(19)68947-7
Theodore Peters, All About Albumin: Biochemistry, Genetics, and Medical Applications ,(1995)
Steven P. Schwendeman, Juan Wang, Mechanisms of solvent evaporation encapsulation processes: prediction of solvent evaporation rate. Journal of Pharmaceutical Sciences. ,vol. 88, pp. 1090- 1099 ,(1999) , 10.1021/JS980169Z
Gaozhong Zhu, Susan R. Mallery, Steven P. Schwendeman, Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide) Nature Biotechnology. ,vol. 18, pp. 52- 57 ,(2000) , 10.1038/71916
Andrew P. Byrnes, Robert E. MacLaren, Harry M. Charlton, Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination. The Journal of Neuroscience. ,vol. 16, pp. 3045- 3055 ,(1996) , 10.1523/JNEUROSCI.16-09-03045.1996
K.A. Houck, D.W. Leung, A.M. Rowland, J Winer, N Ferrara, Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. Journal of Biological Chemistry. ,vol. 267, pp. 26031- 26037 ,(1992) , 10.1016/S0021-9258(18)35712-0
Paolo Mignatti, Daniel B. Rifkin, Nonenzymatic Interactions between Proteinases and the Cell Surface: Novel Roles in Normal and Malignant Cell Physiology Advances in Cancer Research. ,vol. 78, pp. 103- 157 ,(1999) , 10.1016/S0065-230X(08)61024-6
H. Zhu, H. F. Bunn, SIGNAL TRANSDUCTION: How Do Cells Sense Oxygen? Science. ,vol. 292, pp. 449- 451 ,(2001) , 10.1126/SCIENCE.1060849
Napoleone Ferrara, Kari Alitalo, None, Clinical applications of angiogenic growth factors and their inhibitors Nature Medicine. ,vol. 5, pp. 1359- 1364 ,(1999) , 10.1038/70928