Decomposition of N-nitrosamines, and concomitant release of nitric oxide by Fenton reagent under physiological conditions.
作者： K. Hiramoto , Y. Ryuno , K. Kikugawa
DOI: 10.1016/S1383-5718(02)00168-7
关键词:
摘要: Abstract N-Nitrosodimethylamine (NDMA) in phosphate buffer was rapidly decomposed by Fenton reagent composed of H2O2, and Fe(II) ion. Electron spin resonance (ESR) studies using 5,5-dimethyl-1-pyrroline N-oxide (DMPO) showed that characteristic four line 1:2:2:1 ESR signals due to the DMPO-OH adduct formed on treatment DMPO with disappeared presence NDMA, N-nitrosodiethylamine (NDEA), suggesting interaction N-nitrosamines reagent. Treatment generated nitric oxide (NO) as estimated technique cysteine–Fe(II), N-methyl- d -glucaminedithiocarbamate (MGD)–Fe(II) complexes. Characteristic 3, single 2 cysteine–Fe(II)–NO, cysteine–Fe(II)–2 NO complexes, respectively, three MGD–Fe(II)–NO were observed. Considerable amount liberated determined NO2−, final oxidation product reaction dissolved oxygen aqueous medium. Spontaneous release a small from observed only incubation neutral buffers. Above results indicate accompanying concomitant contact reactive species.
elsevier.com
sci-hub.se 参考文章(42)
W. Chamulitrat, S.J. Jordan, R.P. Mason, K. Saito, R.G. Cutler, Nitric oxide formation during light-induced decomposition of phenyl N-tert-butylnitrone. Journal of Biological Chemistry. ,vol. 268, pp. 11520- 11527 ,(1993) , 10.1016/S0021-9258(19)50231-9
R M Palmer, S Moncada, E A Higgs, NITRIC OXIDE: PHYSIOLOGY, PATHOPHYSIOLOGY, AND PHARMACOLOGY Pharmacological Reviews. ,vol. 43, pp. 109- 142 ,(1991)
Rafael Radi, Joseph S. Beckman, Kenneth M. Bush, Bruce A. Freeman, Peroxynitrite-induced membrane lipid peroxidation : the cytotoxic potential of superoxide and nitric oxide Archives of Biochemistry and Biophysics. ,vol. 288, pp. 481- 487 ,(1991) , 10.1016/0003-9861(91)90224-7
Vladimir Yermilov, Julieta Rubio, Michel Becchi, Marlin D. Friesen, Brigitte Pignatelli, Hiroshi Ohshima, Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro Carcinogenesis. ,vol. 16, pp. 2045- 2050 ,(1995) , 10.1093/CARCIN/16.9.2045
Lee Ann MacMillan-Crow, John P. Crow, John A. Thompson, Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues. Biochemistry. ,vol. 37, pp. 1613- 1622 ,(1998) , 10.1021/BI971894B
Sara Goldstein, Gidon Czapski, Kinetics of Nitric Oxide Autoxidation in Aqueous Solution in the Absence and Presence of Various Reductants. The Nature of the Oxidizing Intermediates Journal of the American Chemical Society. ,vol. 117, pp. 12078- 12084 ,(1995) , 10.1021/JA00154A007
Walter A. Prütz, Hans Mönig, John Butler, Edward J. Land, Reactions of nitrogen dioxide in aqueous model systems: Oxidation of tyrosine units in peptides and proteins Archives of Biochemistry and Biophysics. ,vol. 243, pp. 125- 134 ,(1985) , 10.1016/0003-9861(85)90780-5
Kazuyuki Hiramoto, Takumi Ohkawa, Kiyomi Kikugawa, Release of nitric oxide together with carbon-centered radicals from N-nitrosamines by ultraviolet light irradiation. Free Radical Research. ,vol. 35, pp. 803- 813 ,(2001) , 10.1080/10715760100301301
Ching-San Lai, Andrei M. Komarov, Spin trapping of nitric oxide produced in vivo in septic‐shock mice FEBS Letters. ,vol. 345, pp. 120- 124 ,(1994) , 10.1016/0014-5793(94)00422-6
Anatoli N. Saprin, Lawrence H. Piette, Spin trapping and its application in the study of lipid peroxidation and free radical production with liver microsomes. Archives of Biochemistry and Biophysics. ,vol. 180, pp. 480- 492 ,(1977) , 10.1016/0003-9861(77)90063-7