Cardioprotective Properties of HDL: Structural and Functional Considerations.

摘要: BACKGROUND As Mendelian Randomization (MR) studies showed no effect of variants altering HDL-cholesterol (HDL-C) levels concerning Cardiovascular Disease (CVD) and novel therapeutic interventions aiming to raise HDL-C resulted futility, the usefulness is unclear. OBJECTIVE role currently doubtful, it suggested that atheroprotective functions HDLs can be attributed number HDL particles, their characteristics including lipid protein components. Scientific interest has focused on function causes rendering particles dysfunctional, whereas relevance subclasses with CVD remains controversial. METHODS The present review discusses changes in quality as much quantity pathological conditions connection between particle concentration cardiovascular disease mortality. Emphasis given recently available data cholesterol efflux capacity parameters determine functionality, well recent investigations associations RESULTS MR or pharmacological targeting are not favor hypothesis relationship CVD. search biomarkers relate functionality needed. Similarly, size exhibit controversial context further CONCLUSION There room for old concept a silver bullet,as cannot considered robust marker does reflect importance number. Elucidation complex system, finding biomarkers, will allow development any HDL-targeted therapy.