The immune system of cartilaginous fish.

摘要: Chondrichthyes, or cartilaginous fish, are a highly successful group of vertebrates. Most extant species long-lived, display an amazing diversity, and fill all predatory oceanic niches (and few other as well; Wilson 1992). For our purposes, they the oldest vertebrates shown to possess adaptive immune system grounded on immunoglobulins (Ig), T cell receptors (TCR), major histocompatibility complex (MHC) class I II molecules (Litman et al. 1999). The examination these genes, mechanisms recombination somatic mutation antigen receptor well manner by which responses occur in secondary other?) lymphoid tissues, comparison classes, allow us develop paradigms illustrate common ancestor jawed