An acquired chemotactic defect in neutrophils from patients receiving interleukin-2 immunotherapy

摘要: Abstract Bacterial sepsis is a frequent complication in patients with cancer who are receiving high doses of interleukin-2. We evaluated the function neutrophils from such to determine whether there was any abnormality this form host defense. Before interleukin-2 therapy, 31 metastatic were normal assays random migration and chemotaxis. Superoxide production, phagocytosis, secretion granule proteins, bactericidal activity also normal. Neutrophils near end first course had severely impaired chemotaxis response formylated peptide stimulus (mean [±SEM], 49.6±7.4 percent base line; P<0.001). The defect improved 5 10 days after completed therapy but recurred toward second (35.3±6.9 chemotactic (zymosan-activated serum) w...