YTHDC1 gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study

摘要: Abstract Wilms tumor is a common pediatric with abundant genetic drivers. YTHDC1 an important reader of the N6-methyladenosine modification that widely regulates eukaryotic transcripts. has been associated occurrence and development some tumors. However, this first study on gene polymorphisms susceptibility. In brief, we conducted five-center case-control to explore associations between (rs2293596 T > C, rs2293595 rs3813832 T > C) susceptibility in Chinese children. A total 404 cases 1198 controls were successfully genotyped using TaqMan real-time PCR. Odds ratios (ORs) 95% confidence intervals (CIs) used as evaluation indicators. We found children 2–3 risk genotypes more likely develop than those 0–1 (adjusted OR = 1.28, CI = 1.01–1.62, P = 0.042). no other statistically significant results research study. The combined effect significantly increases Our need be verified different populations after increasing sample size controlling for confounding factors.