Ganglion-Blocking Agents in Internal Medicine

摘要: The major therapeutic use of the ganglion-blocking agents is in management arterial hypertension. These were first potent hypotensive drugs to be developed. Initially, tetraethylammonium chloride was used, but later other compounds synthesised and used: hexamethonium, Pendiomid, pentapyrrolidinium (pentoli-nium), mecamylamine, chlorisondamine, pentamethylpiperidine (pempidine), pachy-carpinum, nanophynum, diochinum, dicolinum, dimecolinum, ganglerone, others (see Kharkevich, p. 1, for structures synonyms Russian agents). Although inhibit transmission all autonomic ganglia, sensitivity various ganglia differs. highest noticed pathways system that are a state increased functional overexertion (Paton Zaimis, 1952). Thus, hypertension some peripheral vascular diseases sympathetic react tone decreases; patients with peptic ulcer most sensitive those parasympathetic nervous system, which controls motor secretory activity stomach. Therefore, used treatment different connected disturbance regulation, when decrease efferent impulse organs may produce an expected effect (in smooth muscles, renal colic, causalgias, eclampsia, also surgery creation controlled hypotension, etc.).