Lack of association between plasma levels of non-nucleoside reverse transcriptase inhibitors & virological outcomes during rifampicin co-administration in HIV-infected TB patients.
作者： Geetha Ramachandran , AK Hemanth Kumar , C Ponnuraja , K Ramesh , Lakshmi Rajesh
DOI:
关键词:
摘要: Background & objectives: Among patients with HIV-associated tuberculosis (TB), reduced plasma non-nucleoside reverse transcriptase inhibitors (NNRTI) concentrations during rifampicin (RMP) co-administration could lead to HIV treatment failure. This study was undertaken examine the association between nevirapine (NVP) and efavirenz (EFV) virological outcomes in infected HIV-1 TB. Methods: a nested clinical trial of TB, randomized two different once-daily antiretroviral (ART) regimens along anti-TB (ATT). Trough NVP EFV were estimated at months 1 (during ATT ART) 6 (ART only) by HPLC. Plasma RNA level >400 copies/ml or death within ART considered as unfavourable outcomes. Genotyping CYP2B6 516G>T polymorphism performed. Results: Twenty nine per cent arm had an outcome compared 9 (P T significantly associated virologic receiving EFV-based regimen. Interpretation conclusions: did not show any response on ART. among EFV.
ijmr.org.in参考文章(22)
Awewura Kwara, Margaret Lartey, Kwamena W. Sagoe, Fafa Xexemeku, Ernest Kenu, Joseph Oliver-Commey, Vincent Boima, Augustine Sagoe, Isaac Boamah, David J. Greenblatt, Michael H. Court, Pharmacokinetics of Efavirenz When Co-administered With Rifampin in TB/HIV Co-infected Patients: Pharmacogenetic Effect of CYP2B6 Variation The Journal of Clinical Pharmacology. ,vol. 48, pp. 1032- 1040 ,(2008) , 10.1177/0091270008321790
W Manosuthi, W Mankatitham, A Lueangniyomkul, S Chimsuntorn, S Sungkanuparph, Standard-dose efavirenz vs. standard-dose nevirapine in antiretroviral regimens among HIV-1 and tuberculosis co-infected patients who received rifampicin. Hiv Medicine. ,vol. 9, pp. 294- 299 ,(2008) , 10.1111/J.1468-1293.2008.00563.X
Leena Sathia, Ifeyinwa Obiorah, Graham Taylor, Onn Kon, Marie O'Donoghue, Sara Gibbins, John Walsh, Alan Winston, Concomitant Use of Nonnucleoside Analogue Reverse Transcriptase Inhibitors and Rifampicin in TB/HIV Type 1-Coinfected Patients AIDS Research and Human Retroviruses. ,vol. 24, pp. 897- 901 ,(2008) , 10.1089/AID.2007.0277
Awewura Kwara, Geetha Ramachandran, Soumya Swaminathan, Dose adjustment of the non-nucleoside reverse transcriptase inhibitors during concurrent rifampicin-containing tuberculosis therapy: one size does not fit all. Expert Opinion on Drug Metabolism & Toxicology. ,vol. 6, pp. 55- 68 ,(2010) , 10.1517/17425250903393752
Noritaka Ariyoshi, Masafumi Miyazaki, Kenji Toide, Yu-ichi Sawamura, Tetsuya Kamataki, A Single Nucleotide Polymorphism of CYP2B6 Found in Japanese Enhances Catalytic Activity by Autoactivation Biochemical and Biophysical Research Communications. ,vol. 281, pp. 1256- 1260 ,(2001) , 10.1006/BBRC.2001.4524
Bregt S Kappelhoff, Kristel M L Crommentuyn, Monique M R de Maat, Jan W Mulder, Alwin D R Huitema, Jos H Beijnen, Practical Guidelines to Interpret Plasma Concentrations of Antiretroviral Drugs Clinical Pharmacokinectics. ,vol. 43, pp. 845- 853 ,(2004) , 10.2165/00003088-200443130-00002
Andrew Boulle, Gilles Van Cutsem, Karen Cohen, Katherine Hilderbrand, Shaheed Mathee, Musaed Abrahams, Eric Goemaere, David Coetzee, Gary Maartens, Outcomes of Nevirapine- and Efavirenz-Based Antiretroviral Therapy When Coadministered With Rifampicin-Based Antitubercular Therapy JAMA. ,vol. 300, pp. 530- 539 ,(2008) , 10.1001/JAMA.300.5.530
Weerawat Manosuthi, Somnuek Sungkanuparph, Preecha Tantanathip, Aroon Lueangniyomkul, Wiroj Mankatitham, Wisit Prasithsirskul, Sunantha Burapatarawong, Supeda Thongyen, Sirirat Likanonsakul, Unchana Thawornwa, Vilaiwan Prommool, Kiat Ruxrungtham, , A Randomized Trial Comparing Plasma Drug Concentrations and Efficacies between 2 Nonnucleoside Reverse-Transcriptase Inhibitor-Based Regimens in HIV-Infected Patients Receiving Rifampicin: The N2R Study Clinical Infectious Diseases. ,vol. 48, pp. 1752- 1759 ,(2009) , 10.1086/599114
S. A. Petroff, A NEW AND RAPID METHOD FOR THE ISOLATION AND CULTIVATION OF TUBERCLE BACILLI DIRECTLY FROM THE SPUTUM AND FECES. Journal of Experimental Medicine. ,vol. 21, pp. 38- 42 ,(1915) , 10.1084/JEM.21.1.38
Catia Marzolini, Amalio Telenti, Laurent A. Decosterd, Gilbert Greub, Jérôme Biollaz, Thierry Buclin, Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. AIDS. ,vol. 15, pp. 71- 75 ,(2001) , 10.1097/00002030-200101050-00011