The effect of sinus node depression on heart rate variability in humans using zatebradine, a selective bradycardic agent

摘要: Zatebradine is a bradycardic agent with selective effect on the pacemaker current in sinus node. The of such drugs heart rate variability not known. Thirty-six patients without structural disease were randomly assigned to receive 10 mg zatebradine i.v. (n = 24) or isotonic saline 12). Heart (HRV) was recorded as power very low frequency (VLF, 0.003-0.040 Hz), (LF, 0.040-0.150 and high (HF, 0.150-0.400 Hz) spectral bands well total (TP, 0.003-0.400 during 5-min ECG acquisitions at baseline, 30, 60 min following start infusion. No change detected control group. significantly reduced all bands: VLF (-12 ± 4%, p < 0.001), LF (-19 HF (-26 5%, 0.001). reduction HRV due depression node response external stimuli underscores...