Impact of hypercalcemia and parathyroid hormone level on the sensitivity of preoperative sestamibi scanning for primary hyperparathyroidism.

摘要: Technetium 99m sestamibi scanning (MIBI) can direct unilateral parathyroidectomy. However, the clinical application remains variable with sensitivities ranging from 55 to 100 per cent. We examined whether patient factors including serum calcium (Ca) and parathyroid hormone (PTH) levels impact sensitivity of MIBI. completed a retrospective review 102 patients primary hyperparathyroidism mild hypercalcemia who underwent preoperative All bilateral neck explorations abnormalities confirmed by histopathology. MIBI was correlated Ca PTH using univariate logistic regression analysis. The mean 11.0 mg/dL 158 pg/mL. More than 95 cent greater 11.3 had positive scan as compared 60 those lesser values (P = 0.0024). Similarly level 160 pg/mL scans in 93 opposed 57 lower 0.006). Using scan-directed approach 65 74 would have undergone exploration; this yield 7.7 operative failure rate because contralateral multigland disease. Lower seem correlate reduced Increasing acceptance surgery for minimal may make less attractive without ancillary diagnostic measures such rapid parathormone assays.