Modulation of macrophage antitumor cytostasis by endogenous leukotrienes
DOI:
关键词:
摘要: textabstractUsing resident peritoneal macrophages, this study was focussed on the activating role of endogenous leukotrienes in regulation macrophage antitumor cytostatic activity response to inflammatory stimuli. Inhibitors and inducers leukotrienes synthesis were used to modulate antitumor cytostatic function to identify essential leukotriene(s) enzymes involved in inhibition tumor cell growth by activated macrophages. Induction high modulation of leukotriene biosynthesis might represent an efficient immunotherapeutic tool. - The main aim present work study the possible interrelationship between induction antitumor cytostasis production prostanoids by murine macrophages stimulated with calcium ionophore A23187. A method separation velocity sed~mentation adapted for obtaining macrophage-enriched preparations from macrophage population
参考文章(139)
R F Irvine, How is the level of free arachidonic acid controlled in mammalian cells Biochemical Journal. ,vol. 204, pp. 3- 16 ,(1982) , 10.1042/BJ2040003
PIERRE BORGEAT, MARIE NADEAU, HASSAN SALARI, PATRICE POUBELLE, BERNARD FRUTEAU DE LACLOS, Leukotrienes: biosynthesis, metabolism, and analysis. Advances in lipid research. ,vol. 21, pp. 47- 77 ,(1985) , 10.1016/B978-0-12-024921-3.50008-3
C P Page, P J Barnes, K F Chung, Inflammatory mediators and asthma. Pharmacological Reviews. ,vol. 40, pp. 49- 84 ,(1988)
Shinjiro Todd, Tetsuo Hashida, Yoshitaka Shimizu, Shinsaku Imashuku, Tetsuro Takamatsu, Setsuya Fujita, Cell kinetic studies of PGD2 cytotoxicity on the in vitro growth of human neuroblastoma. Prostaglandins, Leukotrienes and Medicine. ,vol. 23, pp. 55- 65 ,(1986) , 10.1016/0262-1746(86)90078-8
Robert D. Krell, Roberto Levi, Biology of the Leukotrienes ,(1987)
Israel Rehovot, Fortüne Kohen, Zvi Naor, Disease, Uriel Zor, Leukotrienes and Prostanoids in Health and Disease ,(1986)
S V Pizzo, D O Adams, R Farb, K J Kao, Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted neutral proteases. Journal of Immunology. ,vol. 124, pp. 293- 300 ,(1980)
J.L. Humes, S. Sadowski, M. Galavage, M. Goldenberg, E. Subers, R.J. Bonney, F.A. Kuehl, Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages. Journal of Biological Chemistry. ,vol. 257, pp. 1591- 1594 ,(1982) , 10.1016/S0021-9258(19)68075-0
Hillel Koren, George Cianciolo, Christina Jeffs, Andrew T. Huang, Edwin Cox, Richard Metzgar, John Laszlo, C. Y. Tso, C. E. Buckley, William Cashdollar, Wayne D. Brenckman, Virgil S. Lucas, Phase I Study of Pharmacological and Immunological Effects of Human Lymphoblastoid Interferon Given to Patients with Cancer Cancer Research. ,vol. 43, pp. 4458- 4466 ,(1983)
Ronald W. Walenga, Marie J. Stuart, Sherry Boone, Ronald L. Dubowy, Eric J. Werner, Inhibition of Human Malignant Neuroblastoma Cell DNA Synthesis by Lipoxygenase Metabolites of Arachidonic Acid Cancer Research. ,vol. 45, pp. 561- 563 ,(1985)