MicroRNAs in the Central Nervous System and Potential Roles of RNA Interference in Brain Tumors
作者： Benjamin Purow
DOI: 10.1007/978-1-60327-553-8_27
关键词:
摘要: The study of RNA interference, in the form endogenous microRNAs (miRNAs) or exogenous small interfering RNAs (siRNAs), is revealing powerful regulatory mechanisms throughout biology. Though small, these short duplexes can lead to potent suppression their targets. Numerous miRNAs are dysregulated cancers, and several have been shown play oncogenic tumor suppressor roles. also pivotal development function central nervous system. Brain tumors, positioned at intersection both, strongly influenced by miRNAs. Early studies upregulated such as miR-21 miR-221/222 act an fashion, while underexpressed miR-124 miR-7 appear suppress brain formation. siRNAs offer novel targeted approaches treatment tumors. In this chapter we will discuss system, roles potential miRNA- siRNA-based therapeutic strategies neuro-oncology.
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sci-hub.st 参考文章(159)
Victor Ambros, Rosalind C. Lee, Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning. Methods of Molecular Biology. ,vol. 265, pp. 131- 158 ,(2004) , 10.1385/1-59259-775-0:131
Galina Gabriely, Peter S. Linsley, Anna M. Krichevsky, Christine C. Esau, Santosh Kesari, Thomas Wurdinger, Rosetta Inpharmatics, MiR-21 Promotes Glioma Invasion by Targeting MMP Regulators. ,(2008)
Katalin Karikó, Prakash Bhuyan, John Capodici, Drew Weissman, Small Interfering RNAs Mediate Sequence-Independent Gene Suppression and Induce Immune Activation by Signaling through Toll-Like Receptor 3 The Journal of Immunology. ,vol. 172, pp. 6545- 6549 ,(2004) , 10.4049/JIMMUNOL.172.11.6545
Hua Chen, Qiang Huang, Jun Dong, De-Zhong Zhai, Ai-Dong Wang, Qing Lan, Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in vivo. BMC Cancer. ,vol. 8, pp. 29- 29 ,(2008) , 10.1186/1471-2407-8-29
Andrew Fire, SiQun Xu, Mary K. Montgomery, Steven A. Kostas, Samuel E. Driver, Craig C. Mello, Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature. ,vol. 391, pp. 806- 811 ,(1998) , 10.1038/35888
Scott M. Hammond, Emily Bernstein, David Beach, Gregory J. Hannon, An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells Nature. ,vol. 404, pp. 293- 296 ,(2000) , 10.1038/35005107
Elena Vigorito, Kerry L. Perks, Cei Abreu-Goodger, Sam Bunting, Zou Xiang, Susan Kohlhaas, Partha P. Das, Eric A. Miska, Antony Rodriguez, Allan Bradley, Kenneth G.C. Smith, Cristina Rada, Anton J. Enright, Kai-Michael Toellner, Ian C.M. MacLennan, Martin Turner, microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells Immunity. ,vol. 27, pp. 847- 859 ,(2007) , 10.1016/J.IMMUNI.2007.10.009
Carol A. Sledz, Michelle Holko, Michael J. de Veer, Robert H. Silverman, Bryan R.G. Williams, Activation of the interferon system by short-interfering RNAs Nature Cell Biology. ,vol. 5, pp. 834- 839 ,(2003) , 10.1038/NCB1038
Zhenbao Yu, Zhaofeng Jian, Shi-Hsiang Shen, Enrico Purisima, Edwin Wang, Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos Nucleic Acids Research. ,vol. 35, pp. 152- 164 ,(2007) , 10.1093/NAR/GKL1032
Yan Zeng, Eric J Wagner, Bryan R Cullen, Both Natural and Designed Micro RNAs Can Inhibit the Expression of Cognate mRNAs When Expressed in Human Cells Molecular Cell. ,vol. 9, pp. 1327- 1333 ,(2002) , 10.1016/S1097-2765(02)00541-5