Non Alcoholic Fatty Liver Disease: Correlation With Clinical Hormonal and Biochemical Parameters

摘要: BACKGROUND: Non alcoholic fatty liver disease (NAFLD) refers to a wide spectrum of damage, ranging from simple steatosis steatohepatitis (NASH) and cirrhosis. The aim this study was describe the variance clinical laboratory parameters that could play role in development NASH group patients with NAFLD. PATIENTS AND METHODS: Clinical, biochemical histological features 36 NAFLD were analyzed. Insulin leptin serum levels measured Body Mass Index (BMI) insulin resistance (HOMA index) calculated. same analyzed 10 healthy controls. RESULTS: Signs chronic findings advanced fibrosis detected 2 (5,5%), while hepatomegaly frequent finding (21 patients, 58,3%). confirmed 21 (58,3%).Statistically significant difference found between controls BMI (32 vs 25, p=0,002), (33,3 9,5, p=0,015) HOMA index (9,4 2,3 p=0,006). In comparing (FL) we observed similar (31,1 32) BMI, higher (42 22 p=0,044), as well (11 7,5) (22 16,6) although differences did not reach statistical significance. CONCLUSIONS: This confirms important obesity greek patients. A positive correlation is also severity damage degree resistance. I N T R O D U C an increasingly recognized condition steatohepatitis, which can progress should be differentiated resulting secondary causes such genetic disorders (lipodystrophy, dysbetalipoproteinemia, etc), nutritional (starvation, total parenteral nutrition, protein caloric malnutrition drugs (estrogens, glucocorticoids, amiodarone, valproic acid Department Internal Medicine, “SOTIRIA” Hospital, Athens, Greece Laboratory Biochemistry, 401 Pathology , “Sotiria” List οf AbbreviAtions: NAFLD: NASH: Steatohepatitis BMI: FL: Fatty HOMA: Homeostatic Model Assessment