Xenon is not superior to isoflurane on cardiovascular function during experimental acute pulmonary hypertension.

摘要: Background Acute right ventricular afterload increase is a known perioperative challenge for the anaesthetic regime especially patients with compromised ventricle. The accused negative inotropic action of volatile anaesthetics, exception xenon, might be crucial adaptation ventricle. Methods Reversible pulmonary hypertension (mean pressure 40 mmHg) was induced by an infusion stable thromboxane A2 analog U46619 in porcine model (n = 35). effects 70 vol% xenon and 0.9 vol% isoflurane on biventricular function were studied conductance catheter technique. Inflammation myocardial injury quantified using serum probes [tumour necrosis factor α (TNFα), interleukin 6 (IL-6), troponin] tissue [B natriuretic peptide (BNP), TNFα, activated caspase 3] enzyme-linked immunosorbance assays reverse-transcription polymerase chain reaction. Results After wash global haemodynamic parameters remained whereas caused systemic vasodilation. This led to significant decrease mean arterial group cardiac output stable. Both substances did not alter contractility nor they induce changes preload both ventricles. Xenon additional afterload, reduced vascular resistance. No inflammatory response found, higher apoptosis rate expression BNP IL-6 determined ventricle. Conclusions These results do support idea that more beneficial than failure during hypertension. Isoflurane compromise systolic acute PHT it only vasodilation contrast xenon.